MCE products for research use only. We do not sell to patients.
MCE China：Artemether
Brand：MedChemExpress (MCE)
Cat. No.HY-N0402
CAS：71963-77-4
Synonyms：Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224
Purity：98.42%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria.
In Vitro：Artemether (0-200 μg/mL, 24-72 h) inhibits rat C6 glioma cell growth in a dose- and time-dependent manner[2]. Artemether (0-10 μM, 72 h) inhibits RANKL-induced osteoclast (osteoclast precursor cells (BMMs)) formation and related gene expression (TRAP, NFATc1, V-ATPase-d2, CTSK, DC-STAMP, MMP-9)[2]. Artemether (48 or 96 h) inhibits ConA- or alloantigen-induced BALB/c splenocyte proliferation (IC50: 6.3 and 3.5 μM)[4]. Artemether (0-50 μM, 16-36 h) inhibits production of the IL-2 and IFN-γ in BALB/c splenocyte[4]. Artemether (0-50 μM, 72 h) inhibits ConA-induced splenocyte, CD4+T- and CD8+ T-cell divisions, and inhibits cell cycle progression through G1/S transition[4].
In Vivo：Artemether (0-66 mg/kg, p.o.) inhibits tumor growth and angiogenesis in SD rats bearing C6 glioma cells[2]. Artemether (10 mg/kg, i.p., 8 days) protects mice against LPS-induced osteolytic bone loss[3]. Artemether (50 and 100 mg/kg, p.o.) inhibits T-cell-mediated immune responses (ear swelling) in DNFB-induced DTH model in BALB/c mice[4].
IC50 & Target：Plasmodium
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